| Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2014) | |
| Biomaterial Interfaces | Thursday Sessions |
| Session BI-ThM |
| Session: | Plasma Bio, Medicine & Agriculture |
| Presenter: | Adoracion Pegalajar-Jurado, Colorado State University |
| Authors: | A. Pegalajar-Jurado, Colorado State University M.J. Hawker, Colorado State University B.S. Neufeld, Colorado State University M.M. Reynolds, Colorado State University E.R. Fisher, Colorado State University |
| Correspondent: | Click to Email |
Current medical device are often affected by biofouling issues, including blood clot formation and bacterial infection. To combat undesirable side effects and severe medical complications related to the fouling of the devices, a dual approach is required where tuned surface properties and localized delivery of specific biomolecules are combined to enhance device performance. To accomplish this, advanced material platforms are needed to achieve localized therapeutic action and customizable surface properties. Although several wet chemical methods have been explored for surface modification, these methods can produce irreproducible surface modifications resulting from non-uniform coatings and/or can interfere with drug delivery mechanisms. An alternative technique that alleviates many of these issues is plasma surface modification, which offers a tunable and versatile parameter space for tailored and reproducible surface modifications for specific applications while retaining the bulk properties of the material. Herein, we describe the surface modification of a variety of drug delivery systems (including S-nitrosated polymer derivatives) via plasma treatment, resulting in a device that maintained their releasing capabilities (i.e. release of nitric oxide (NO)), but exhibited tailored surface properties for specific applications. As a prototype drug delivery system, we have used S-nitrosated poly(lactic-co-glycolic acid)-based hydrophobic polymer to achieve a material capable of releasing the therapeutic agent NO. The S-nitrosated polymer derivative was modified via H2O plasma treatment, resulting in a superhydrophilic material (water droplet spread completely in <100 ms) that retained 90% of its initial S-nitrosothiol content. Under thermal conditions, NO release profiles were identical to controls. Under buffer soak conditions, the NO release profile was slightly lowered for the plasma-treated materials; however, they still result in physiologically relevant NO fluxes. Correlations between this data and those recorded from other plasma treated drug delivery systems will also be discussed.